| RESEARCH ARTICLE |
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| Year : 2006 | Volume
: 27
| Issue : 3 | Page : 55-62 |
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A Toxicity Study of Makaradhwaja Prepared by Astasamskarita Parada
BJ Patgiri1, PK Prajapati2, B Ravishankar3
1 Lecturer, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
2 Reader & Head, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Head, Pharmacology laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
Correspondence Address:
B J Patgiri
Lecturer, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar
India
 Source of Support: None, Conflict of Interest: None  | Check |
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Makaradhwaja is a well known Ayurvedic medicine prepared by Kupipakwa method. It is prepared by using shuddha Swarna (Gold), Astasamskarita Parada (Mercury) and shuddha Gandhaka (Sulphur) in the ratio of 1:8:16 as ingredients. The present study was under taken to ascertain the safety aspect of the drug through acute and chronic toxicity studies. Acute toxicity study was carried out in Swiss albino mice and chronic toxicity study was carried out in Charles Foster albino rats at different dose levels. The parameters studied were ponderal, haematological, biochemical and histopathological. in case of chronic toxicity study, mortality and behaviour change in acute toxicity. In acute toxicity study the test drug did not produce mortality up to the dose of 480 mg kg-1 (orally) in mice. The result or data obtained during the study indicate no significant changes observed in hematological, biochemical and histopathological parameters except of mild increase in blood sugar level and mild fatty changes in liver. |
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