Pharmacological Evaluation of Shinshapa (Dalbergia sissoo Roxb.) stem bark as Analgesic and Anti-inflammatory activities

Arti Rupani; BR Patel; VJ Shukla; B Ravishankar; PP Sharma

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RESEARCH ARTICLE

Year : 2008 | Volume : 29 | Issue : 4 | Page : 215-219

Pharmacological Evaluation of Shinshapa (Dalbergia sissoo Roxb.) stem bark as Analgesic and Anti-inflammatory activities

Arti Rupani¹, BR Patel², VJ Shukla³, B Ravishankar⁴, PP Sharma⁵
¹ Lecturer in Dravyaguna, Govt. Ayurveda College, Junagadh, India
² Lecturer, Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
³ Head - Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
⁴ Head - Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
⁵ HOD - Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Arti Rupani
Lecturer in Dravyaguna, Govt. Ayurveda College, Junagadh
India

Source of Support: None, Conflict of Interest: None

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Shinshapa (Dalbergia sissoo Roxb.) belongs to family Fabaceae. Stem bark of Shinshapa is mentioned in Gridhrasi (Sciatica) by Acharya Vangasena. It suggests that Shinshapa may have analgesic and anti inflammatory properties. No references available on Pharmacological activity in the form of Ghanavati of stem bark of Shinshapa. To provide experimental basis to it, this study has taken up. Shinshapa (Dalbergia sissoo Roxb.) Ghana vati (Dried water extract) as test drug and Parijata (Nyctanthes arbortristis Linn.) Ghana vati (Dried water extract) as reference standard drug were assessed for analgesic and anti inflammatory effect on Wistar strain albino rats and Swiss albino mice at a dose level of 200mg/kg po and 260 mg/kg po respectively. Dose fixation was done according to Paget and Barnes (1969). Anti inflammatory activity was evaluated by employing, Carageenan induced hind paw oedema in albino rats and Formaldehyde induced hind paw oedema in albino rats, while analgesic effect was evaluated by employing, Formaldehyde induced paw licking in albino rats and Tail Flick Response in mice. Result indicates presence of only the moderate effect in reference standard- Parijata and weak to moderate anti-inflammatory and moderate analgesic activity in the test drug- Shinshapa. Thus it can be suggested that this study failed to provide an un-equivocal experimental evidence as basis for their clinical efficacy in the treatment of Gridhrasi (Sciatica).

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