Login   |  Users Online: 1006 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Search Article 
Advanced search 
   Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts

Year : 2010  |  Volume : 31  |  Issue : 1  |  Page : 19-23 Table of Contents     

Evaluation of Dhatri Avaleha as adjuvant therapy in Thalassemia (Anukta Vyadhi in Ayurveda)

1 Lecturer, Kaumarabhritya, SRM State Ayurvedic College, Bareilly (U.P.), India
2 Head of the Dept. of Kaumarabhritya, I.P.G.T. & R.A, India
3 M. D. (Ped.), Hon. Pediatrician, Jamnagar, India

Date of Web Publication7-Aug-2010

Correspondence Address:
Ruchi Singh
Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-8520.68199

Rights and Permissions

Thalassemia is the commonest single gene disorder in India. About 10,000 infants with Thalassemia major are born every year. The present study was under taken with a hope to prevail better quality of life to the Thalassemic patients. Pallor being the chief complaint, a randomized controlled trial was undertaken with Dhatri Avaleha as it is specially mentioned for Pandu, Kamala & Haleemaka Roga. Children between age group of 1 to 15 years were randomly divided in two groups: Drug treated group (Group A) and Control group (Group B). Assessment was done on subjective and objective parameters after 30 and 60 days of treatment with follow up of two month. Statistically significant (P<0.01) result was obtained in Blood transfusion interval in group 'A' in comparison to group 'B'. Dhatri Avaleha may have a potential to increase blood transfusion interval and decrease secondary infection and thus it can be used as supportive therapy with modern medical management.

Keywords: Thalassemia, Pandu, Kamala, Haleemaka, Dhatri Avaleha

How to cite this article:
Singh R, Patel K S, Anand I P. Evaluation of Dhatri Avaleha as adjuvant therapy in Thalassemia (Anukta Vyadhi in Ayurveda). AYU 2010;31:19-23

How to cite this URL:
Singh R, Patel K S, Anand I P. Evaluation of Dhatri Avaleha as adjuvant therapy in Thalassemia (Anukta Vyadhi in Ayurveda). AYU [serial online] 2010 [cited 2023 Jun 3];31:19-23. Available from: https://www.ayujournal.org/text.asp?2010/31/1/19/68199

   Introduction Top

Today is the era of advancement, which can be seen in each field either it might be media, electronic, science or in the day-to-day life i.e. dietetic habits, daily routines as well, hence the ultimate effect of all these changes go towards the problems in coming generation [1] . These changes occur in the field of medical science too, among them Thalassemia is a new disease for Ayurveda and thus called as "Anukta Vyadhi''.

Thalassemia is an inherited blood disorder in which body is unable to make adequate hemoglobin, which is present in the red cells. Normally red cells survive for 120 days but in Thalassemia red cell survival is reduced. In India the combined carrier rate of b Thalassemia, HbE & Sickle Cell Anemia is 3.9%. i.e. 3 crore Indians are Thalassemic carriers and 8000 to 10,000 Thalassemia major are born every year in India. The prevalence for b Thalassemia carrier state varies 0-17% in different ethnic groups. It is very high among certain communities like Punjabis, Sindhis, Gujaratis (Lohana and Bhanushali), Bengalis, Parsis. Thus the morbidity and mortality of this disease has aroused a lot's of research for its alleviation and cure. So keeping all these views in mind great hopes are being laid on Ayurveda as cost effective adjuvant therapy in Thalassemia [2] to prevent its complication and hazardous effects.

The present study is an attempt to analyze the efficacy of Dhatri Avaleha[3] in management of Thalassemia in comparison to a control group managed by routine modern therapy. The drug had been chosen keeping in view its Rasayana, Antioxidant and Hepatoprotective properties.

The main aim of study was to provide a better quality of life and to reduce complication and delay the blood transfusion interval by Ayurvedic medicines.

   Material and Methods Top

Selection of patients:Patients attending the I.P.D. of Thalassemia ward of M. P. Shah Medical College and O.P.D. of Kaumarabhritya Department, I.P.G.T & R.A. Hospital, Jamnagar fulfilling the criteria of selection were incorporated in the study irrespective of age, sex, caste etc.

Criteria for selection of patients: On the basis of clinical sign and symptoms, pathological investigations.

  1. Patients having Hb <10 gm% were selected.
  2. With the clinical manifestation of disease in the age group 1-15 years.

Sampling method: Random sampling

Criteria for exclusion of patients:

  1. Complicated cases of Thalassemia (like HIV, Hepatitis B or other viral diseases etc.).
  2. Patients having Blood Transfusion interval < 15 days.

Assessment criteria

A detailed proforma was prepared which has clinical parameters (subjective and objective) with the score. The score can be counted before and after 30 days, 60 days of treatment. The parameters were as follows:

Subjective parameters

Balakshaya (Fatigue), Sandhi Shoola (Joint pain), Udar Shoola (Abdominal pain), Shramaja Shwasa (Dyspnoea), Avasada (Depression), Panduta (Pallor), Pleehavriddhi (Spleenomegaly), Yakritvriddhi (Hepatomegaly), Irritable bowel syndrome, Blood transfusion interval duration.

Objective parameters

Routine hematological investigation (Hb%, TLC, DLC, ESR, PCV, MCV, MCH, MCHC, and Routine biochemical investigations (S. Alb, S.Glob, SGOT, SGPT, S. Alk. Phosphatase, S. Bil.).

  • A special proforma was made to study the etiopathogenesis as well as response to the given treatment and any complication.

Description of grades and its relation with severity:

For the purpose of statistical assessment of results, we have used some grades, grade point considering the severity of different sign and symptoms and laboratory findings as follows:

[Additional file 1]

Assessment of result

Maximum Improvement: Above 75% relief in clinical sign and symptoms along with blood transfusion interval increases more than 10 days.

Moderate Improvement: Above 50% to 75% relief in clinical sign and symptoms along with blood transfusion interval increases more than 5 to 10 days.

Mild Improvement: Above 25% to 50% relief in clinical sign and symptoms along with blood transfusion interval increases up to 5 days.

No Improvement: Equal or Less than 25% relief in clinical sign and symptoms and blood transfusion interval have no change.

Statistical analysis

Student 't' test (paired and unpaired) was used for assessing the result of clinical study.

Duration of trial: Treatment Period - 60 days [02 months].

Follow up: 02 months.

Procedure of drug administration:

Trial drug:
These drugs consist of the following ingredients in equal ratio as stated by Acharya Charaka in Pandu Roga Chikitsadhikara [3] .

This Avaleha form of drug was prepared according to classical method and administered in scheduled dose according to age group-

   Observations and Results Top

Total 19 patients were enrolled with 11 patients in Group 'A' & 8 patients in Group 'B'. In the Group 'A' 8 patients completed the course of treatment with follow up and in Group 'B'6 patients were continued under observation. Among 19 patients 09 (47.37%) belonged to an age group of 1 to 5 years. It may be due to that most of the Thalassemic patients (Thalassemia major) are diagnosed within the age group of 1 year [4] . Male and female ratio was found almost equal. Maximum number i.e. 14(73.68%) were Hindu, it might be due to dominancy of Hindu in Jamnagar district. The incidence of Thalassemia was maximum i.e. 03 (15.79%) present in Lohana and Kumahar community in comparison to others. Because it is more common in these Gujarati community (Lohana, bhanushali and katchi et.) [5] . Majority of the patients i.e. 12 (63.61%) were diagnosed within the age of 1 yr6. It may be due to clinical manifestation of Thalassemia major starts within the age of first year of life . Before starting the trial drug no. of blood transfusion was found > 100 times in 04 (21.05%) patients. It might be due to rapid breakdown of RBCs leading to severe anemia which can only be compensated by blood transfusion. It was observed that maximum i.e. 16 (84.21%) patients were having Thalassemia major because of ί Thalassemia major prevalent in Gujarat and as well in India. Most of the patients i.e. 13 (68.42%) found not taking any iron chelators. The reason behind not taking iron chelators because of these drugs are very costly and most of the patients were belonging to lower socio-economic group. During surgical history majority i.e. 17 (89.47%) patients having splenectomy not done; it might be due to most of the patient registered from G. G. Singh, hospital were under regular blood transfusion. Only 06 (31.58%) patients were having consanguieous marriage history in parents. It may be due to that most of the patients were from Hindu religion.

Most of the patients i.e.08 (42.11%) were having hepato - spleenomegaly, which may be due to regular blood transfusion. Only 07 patients, parents were investigated for Nestroft0 . It shows unawareness and educational status of the parents. Amla and Katu Rasa predominance were observed in 13 (68.42%) patients, while Guru and Snigdha Guna predominance found in 17(89.47%) and 11(57.89%) patients respectively. During study Vata-Pitta Prakriti was found predominant in 16 (84.21%) patients it might be due to Rakta dushti.

Among chief complaints, pallor was found in 100% patients, while 89.47% patients showed the symptoms of fatigue, joint pain, abdominal pain, dyspnoea was found in 68.42% patients. The 52.63% patients having arrhythmia, 47.37% patients had spleen enlargement, 42.11% patients had symptoms of Irritable bowel syndrome. Chest pain and Depression was found only in 05.26% patients.

In this present clinical study, maximum i.e. 55.99% patients having Dushti of Raktavaha Srotas, 43.15% patients had Rasavaha Srotodushti, while 30.05% patients had Dushti of Medavaha Srotas. The 23.53% and 23.94% patients had Mamsavaha and Majjavaha Srotodushti respectively. Asthivahasrotodushti was found only in 24.18% patients.

After the completion of treatment with follow up result obtained in 08 patients of Group A (Dhatri Avaleha) i.e highly significant (p<0.001) in fatigue, significant (p<0.01) in abdominal pain and pallor, while insignificant (p>0.10) in joint pain, depression spleenomegaly, and irritable bowel syndrome.

The result obtained in 06 patients of Group B (Control group) in which patient were under observation showed insignificant result in all the symptoms with the negative percentage values.

In associated complaints of Group 'A' (Treated group) this therapy provided highly significant (p<0.001) result in Aruchi with the percentage of 92.86%, significant (p<0.05 &0.01) result in Alasya, Mandagni, Rurti and Trishna with the percentage of 100%, 81.82%, 75%, 44.45% relief respectively, while insignificant (p>0.10) result obtained in Angamarda with 25% relief only.

In Group B (Control Group), statistically insignificant result was observed with the 11.43% relief in Aruchi, 25% in Angamarda, 12.50% in Mandagni, no relief in Aalasya and Recurrent respiratory infection and -20% in Trishna.

In blood transfusion interval duration statistically significant (p<0.01) result found during first interval duration in Group A (Trial Group) comparative to Group B (Control Group). In objective parameters both the group showed insignificant results. [Table 1], [Table 2], [Table 3] and [Table 4]
Table 1 :Improvement in chief complaints after treatment

Click here to view
Table 2 :Improvement in associated complaints after treatment

Click here to view
Table 3 :Effect of therapy in blood ransfusion interval duration

Click here to view
Table 4 :Result of clinical assesment in 14 patients

Click here to view

   Discussion Top

Intake of tea in small children fascinated, which is generally supported by doctors mostly due to its iron chelating property. Predominance of anger and irritation due to prolong ill health, different types of restriction, isolation and vitiation of Pitta Dosha.

On the basis of special proforma Vata-Pitta predominance was observed along with Rakta Dushti. The symptoms described in Haleemaka Vyadhi in Charaka Samhita Chikitsa (16/132,133) seem to be very nearer to Thalassemia as follows: Haritashyavapeetakaha, this varna seems to be yellowish brown colour in thalassemia due to excess iron deposition beneath the skin. Other features like Balautsaha kshaya, Tandra, Mandagni, Mridujwara, Angamarda, Shwasa, Trishna and Aruchi, are clinically found predominant in Thalassemic patients.

As pallor or Raktalpata is the main cardinal feature of the disease for which patients seeks medical help. Thus the name of the disease can be given as: Kulaja Pandu (Raktalpata) in Bala / Anuvanshika Pandu (Raktalpata) in Bala / Anuvanshika Tridoshaja Pandu (Raktalpata) in Bala / Beeja Dushti Janya Pandu (Raktalpata) in Bala. But after detailed literary and clinical research conclusion can be drawn that Thalassemia may be simulated with the disease Haleemaka. Ayurvedic formulations along with supportive modern therapy may provide better quality of life to the diseased.

   Conclusion Top

Dhatri Avaleha may have a potential to reduce blood transfusion interval duration along with other secondary infection. It can be given as supportive therapy with modern medical management.[10]

   References Top

1.Taneja Anubha, Expectations and obligations of Thalassemic, 5th national Thalassemia conference 11th, 12th November 2006 (119-120), MAMC Auditorium, New Delhi.  Back to cited text no. 1      
2.Varma I.C., Puri R., Thakur S., Saxena R., Strategies for control of ί-thalassemia in India, 5th national Thalassemia conference 11th, 12th November 2006 (76-82), MAMC Auditorium, New Delhi.  Back to cited text no. 2      
3.Charaka Samhita with 'Vidyotini Hindi Commentary by Pt. Kashinath Shastry and Dr. Gorakhnath Chaturvedi, Part I and 2, Chaukhamba Bhauati Academy, Varanasi, 1998.  Back to cited text no. 3      
4.I.A.P. Text book of Pediatrics Edi. A Parathasarathy, Jaypee Brothers New Delhi, Ist Edition, 2000.  Back to cited text no. 4      
5.Deeka Deepika, Public Awareness and Prevention of Thalassemia Major, National Thalassemia Bulletin, Vol.11 No, 2 May 2005.  Back to cited text no. 5      
6.Rudolf's Pediatrics Edi. Abraham M. Rudolf PH., Prentice Hall International INC, XXth Edition, 1996.  Back to cited text no. 6      
7.Agrawal M.B., Rathi A. Shyam, Gene therapy in thalassemia, 5th national Thalassemia conference 11th, 12th November 2006 (94-103), MAMC Auditorium, New Delhi.  Back to cited text no. 7      
8.Solkar M.H., Mamta Manglani, Psychosocial evaluation in Thalassemic children; 1st international Symposium on Thalassemia, 8th - 9th Octobar, 2005 (44) Pune.  Back to cited text no. 8      
9.Agrawal M.B, Total managment of Thalassemia: advances, 1st international Symposium on Thalassemia, 8th -9th Octobar, 2005 (38) Pune.  Back to cited text no. 9      
10.Agrawal M.B, Agrawal U.M., Rajadhyaksha, Munot Sameer, Assesment of cardiac iron overload: Role of MRI; 1st international Symposium on Thalassemia, 8th -9th Octobar, 2005 (36) Pune.  Back to cited text no. 10      


  [Table 1], [Table 2], [Table 3], [Table 4]

This article has been cited by
1 Management of Children With -Thalassemia Intermedia
Amira A. Adly,Eman A. Ismail
Journal of Pediatric Hematology/Oncology. 2018; 40(4): 253
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Material and Methods
    Observations and...
    Article Tables

 Article Access Statistics
    PDF Downloaded869    
    Comments [Add]    
    Cited by others 1    

Recommend this journal