Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice

Yogesh S Deole; Sulakshan S Chavan; BK Ashok; B Ravishankar; AB Thakar; HM Chandola

doi:10.4103/0974-8520.93918

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PHARMACOLOGICAL RESEARCH

Year : 2011 | Volume : 32 | Issue : 3 | Page : 375-379

Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice

Yogesh S Deole¹, Sulakshan S Chavan², BK Ashok³, B Ravishankar⁴, AB Thakar⁵, HM Chandola⁶
¹ Lecturer, Department of Kayachikitsa, GJ Patel Ayurveda College and Research Centre, New Vallabh Vidya Nagar, India
² Ph.D.Scholar, Pharmacology Laboratory, IPGT & RA, Jamnagar, India
³ Research Assistant, Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, India
⁴ Director, Research and Development, SDM College of Ayurveda, Udupi, Karnataka, India
⁵ Associate Professor and I/c Head, Department of Panchakarma, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, India
⁶ Professor and Head, Department of Kayachikitsa, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, Gujarat, India

Correspondence Address:
Yogesh S Deole
Lecturer, Department of Kayachikitsa, G J Patel Ayurveda College and Research Centre, New Vallabh Vidya Nagar, Gujarat
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0974-8520.93918

In recent years, many Ayurvedic formulations are being researched to provide an effective antidepressant and anxiolytic drug in the field of psycho-pharmacology. The present study was planned to evaluate the anti-depressant and anxiolytic activity of Rasayana Ghana Tablet comprising three herbs Guduchi (Tinospora cordifolia Miers), Aamalaki (Emblica officinalis Garten) (RGT) and Gokshura (Tribulus terrestris Linn). Swiss albino mice were divided into four groups of six animals each, comprising of both male and female in each group. Group I received water served as normal control (WC), group II received vehicle and served as vehicle control (VC), group III received Rasayana Ghana tablet and group IV received standard drug diazepam (2 mg/kg) for anxiolytic study in elevated plus maze and standard antidepressant imipramine (5 mg/kg) for anti-depressant activity in behavior despair test. Rasayana Ghana tablet along with ghee and honey as vehicle is found to be having antidepressant and anxiolytic activity in experimental animals. Thus, this formulation can be used in prevention and treatment of depression and anxiety.

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