Anti-anxiety and anti-depressant activities of Sarasvata choorna in experimental animals

Kshama Gupta; BK Ashok; B Ravishankar; AB Thakar

doi:10.4103/0974-8520.96139

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PHARMACOLOGICAL RESEARCH

Year : 2011 | Volume : 32 | Issue : 4 | Page : 590-593

Anti-anxiety and anti-depressant activities of Sarasvata choorna in experimental animals

Kshama Gupta¹, BK Ashok², B Ravishankar³, AB Thakar⁴
¹ Lecturer, Department of Kaya Chikitsa, Guru Nanak Ayurvedic Medical College and Hospital, Muktsar, Punjab, India
² Research Assistant, Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
³ Director, Research and Development, SDM Research Centre for Ayurveda and Allied Sciences, Udupi, Karnataka, India
⁴ Associate Professor and I/C Head, Department of Panchakarma, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
Kshama Gupta
Lecturer, Departmentt of Kaya Chikitsa, Guru Nanak Ayurvedic Medical College and Hospital, Near Ajit Cinema Barkandi Road, Muktsar, Punjab 152026
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0974-8520.96139

The present study was undertaken to evaluate the anxiolytic and anti-depressant activity of Sarasvata choorna. The anxiolytic activity was evaluated in elevated plus maze (EPM) and the anti-depressant activity was evaluated in forced swimming test (FST). The efficacy of Sarasvata choorna was compared with the standard anti-anxiety (diazepam 2 mg/kg) and anti-depressant (imipramine - 5 mg/kg) drugs. It was observed that Sarasvata choorna at the dose of 390 mg/kg is as effective as standard drugs used in anti-anxiety and anti-depressant activities in mice by increasing time spent in open arm and entries to open arm in EPM model and increasing immobility time in FST model respectively. Hence it can be concluded that Sarasvata choorna may be used as a potent therapeutic agent in treating anxiety and depressive disorders.

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