| PHARMACOLOGICAL STUDY |
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| Year : 2012 | Volume
: 33
| Issue : 2 | Page : 299-302 |
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In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L.
Md. Torequl Islam1, Md. Abdun Noor2, Bijoy Karon2, Rivelilson Mendes de Freitas3
1 Lecturer, Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Chittagong, Bangladesh
2 M. Pharm. Scholar, Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Chittagong, Bangladesh
3 Professor, Department of Biochemistry and Pharmacology -CCS-UFPI, Post Graduate Program in Pharmaceutical Sciences, Campus Minister Portella - Bairro ining, Teresina, Brazil
Correspondence Address:
Md. Torequl Islam
Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Shaheed Mirza Lane (East), Mehedibag Road, Chittagong
Bangladesh
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.105256
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Plants are rich source of pharmacologically active agents, which could be explored in disease management. Methanol, ethanol, and petroleum ether extracts of the whole plant of Allophylus cobbe L. were evaluated for antimicrobial and cytotoxic activities. In vitro antimicrobial sensitivity by disk diffusion method was conducted against four Gram-positive and seven Gram-negative pathogenic bacteria and seven fungi. In the antibacterial and antifungal sensitivity tests, growth inhibition was found to be within the range of 10.0-17.67 mm. Strong zone of inhibition by the ethanol extract of A. cobbe (EEAC) was found against Trichophyton spp. With some exceptions, a mild to strong antimicrobial activity was observed in this study. Significant minimum inhibitory concentration (MIC; 15.625 μg/ml) was found against Trichophyton spp. Other detected MICs were within the range of 31.25-125 μg/ml. The petroleum ether extract of the plant exhibited strong cytotoxicity in the brine shrimp lethality bioassay test. |
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