Anti-inflammatory activity of two varieties of Pippali (Piper longum Linn.)

Mamta Kumari; BK Ashok; B Ravishankar; Tarulata N Pandya; Rabinarayan Acharya

doi:10.4103/0974-8520.105258

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PHARMACOLOGICAL STUDY

Year : 2012 | Volume : 33 | Issue : 2 | Page : 307-310

Anti-inflammatory activity of two varieties of Pippali (Piper longum Linn.)

Mamta Kumari¹, BK Ashok², B Ravishankar³, Tarulata N Pandya⁴, Rabinarayan Acharya⁵
¹ Medical Officer, Central Government Health Scheme, Ayurved Dispensary, New Delhi, India
² Research Assistant, Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, Gujarat, India
³ Director, Research and Developement, SDM College of Ayurveda, Udupi, Karnataka, India
⁴ Ex. Reader and I/C Head, Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
⁵ Associate Professor, Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
B K Ashok
Pharmacology Lab, IPGT and RA, Dhanvantri Mandir, Gujarat Ayurved University, Jamnagar
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0974-8520.105258

The present study has beenundertaken to evaluate the anti-inflammatory activity of two varieties of Pippali in acute and sub-acute experimental models of inflammation in albino rats. Four different market samples of each variety of Pippali were procured from different regions of India. The samples collected from South India which have given more extractive values were selected for screening of anti-inflammatory activity. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 200 mg/kg and the activity was compared with standard anti-inflammatory drugs in both models. Among the two different test samples studied, it was found that Chhoti variety of Pippali suppressed inflammation of both acute and sub acute phase, while Badi variety of Pippali only of acute phase. Thus for the therapeutic utility, Chhoti variety of Pippali may be considered over the Badi variety.

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