| PHARMACOLOGICAL STUDY |
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| Year : 2013 | Volume
: 34
| Issue : 1 | Page : 113-117 |
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Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation
M Shreevathsa1, B Ravishankar2, Rambabu Dwivedi3
1 Professor and Head, Department of Post Graduate Studies in Ayurveda Siddhanta, Government Ayurveda Medical College, Mysore, India
2 Director, Research and Development, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka, India
3 Professor and Head, Department of Basic Principles, Institute for Post Graduate Training and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
Correspondence Address:
M Shreevathsa
Department of Post Graduate Studies in Ayurveda Siddhanta, Government Ayurveda Medical College, Mysore, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.115448
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Depression is a psychiatric condition in which there is loss of interest in all pleasurable outlets, viz. food, sex, work, friends, hobbies and entertainment. The prevalence rate of the disease is 6-8% in women and 3-5% in men. Ayurveda, the science of life, provides systematic management principles for depression. Mamsyadi Kwatha is one such formulation stated by Yadavji Trikamji Acharya in Siddha Yoga Sangraha and Bheshaja Samhita, which is said to be effective in psychiatric conditions. The ingredients are Jatamansi (Nardostachys jatamansi), Ashwagandha (Withania somnifera) and Parasika Yavani (Hyocymus niger) in an 8:4:1 ratio, respectively. The test drug was subjected for antidepressant activity in experimental models. The models selected for anti depressant activity were behavioral despair test, anti-reserpine test and Chronic Fatigue Syndrome (CFS) test in albino mice. The test formulation showed significant inhibition of behavioural despair (P < 0.05), weak to moderate anti-reserpine activity - ptosis (P < 0.001), catatonia (P < 0.01), sedation (P < 0.01) and moderate effect in CFS test (P < 0.050). These effects clearly show that Mamsyadi Kwatha has an anti-depressant activity. |
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