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Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistar albino rats
N Thamizh Selvam1, V Venkatakrishnan2, R Dhamodharan3, S Murugesan4, S Damodar Kumar5
1 Research Officer-Biochemistry, National Research Institute for Panchakarma, Cheruthuruthy, Kerala, India
2 Faculty of Microbiology, Pondicherry University, Pondicherry, India
3 Associate Professor, Department of Botany, Presidency College, Chennai, Tamil Nadu, India
4 Associate Professor, Department of Botany, Pachaiyappa's College, Chennai, Tamil Nadu, India
5 Associate Professor, Department of Chemistry, Pachaiyappa's College, Chennai, Tamil Nadu, India
Correspondence Address:
N Thamizh Selvam
Research Officer-Biochemistry, National Research Institute for Panchakarma, CCRAS, Department of AYUSH, Ministry of Health and FW, Govt. of India, Cheruthuruthy, Kerala
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.123133
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Hepatoprotective activity of methanolic extract of Syzygium jambos (Alston) (Linn.) leaves against Paracetamol-induced hepatic damage in Wistar albino rats was observed at two different doses, 100 and 200 mg/kg body weight. The healthy control, disease control, and standard drug Silymarin-treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALKP, Serum Bilirubin and other metabolic parameters like total cholesterol, HDL-cholesterol were evaluated in all the experimental groups. The changes in liver function parameters were significant in comparison to disease control group and the observed efficacy was comparable to standard drug. The efficacy of the extract was found to be dose dependent. The histopathology study of liver also supports the presence of hepatoprotective activity in S. jambos by showing improved cytoarchitecture of liver cells in the treated groups. The results obtained in this study indicate necessity for further research on isolation and characterization of functional molecules from the extract. |
