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Hypoglycemic and antihyperglycemic activity of Saptarangyadi Ghanavati: An Ayurvedic compound formulation
Kanwar Samrat Singh1, BK Ashok2, Mandip Kaur3, B Ravishankar4, Hari Mohan Chandola5
1 Department of Kayachikitsa, SKSS Ayurvedic College, Sarabha, Ludhiana, Punjab, India
2 Research and Development, The Himalaya Drug Company, Bengaluru, Karnataka, India
3 Department of Kayachikitsa, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
4 SDM Research Centre for Ayurveda and Allied Sciences, Udupi, Karnataka, India
5 Ch. Brahm Prakash Charak Ayurved Sansthan, New Delhi, India
Correspondence Address:
Kanwar Samrat Singh
H. No. 273/3, Tej Colony, Tehsil - Samana, Patiala, Punjab - 147 101
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.146248
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Background: Diabetes mellitus is a persistent health problem that requires innovative strategies to improve health and needs a multifactorial approach for the treatment. Saptarangyadi Ghanavati, a formulated Ayurvedic compound consists of herbs with anti-diabetic potential. Aim: To evaluate the hypoglycemic and antihyperglycemic activities of Saptarangydi Ghanavati. Materials and Methods: For hypoglycemic activity 18 Swiss albino mice were divided into three groups (6 in each). First group served as normal control, second group is the test drug and third is the standard control group. For antihyperglycemic activity 24 Swiss albino mice were divided into four groups (6 in each). First group served as water control, second negative control, third test drug and fourth as standard control group. Test drug Saptarangydi Ghanavati was suspended in water and administered to animals at the dose of 400 mg/kg. Glibenclamide was used as reference standard in both the models at the dose of 0.65 mg/kg. Results: Saptarangyadi Ghanavati showed mild reduction in Blood Sugar Level (BSL) at all the time intervals in normoglycemic mice; however, the observed decrease of BSL was found to be statistically non significant. In antihyperglycemic activity, even though the drug failed to cease the hyperglycemia in the first hour after the glucose overload, it attenuated the same in later hours in nonsignificant extent. Conclusion: The study reveals that Saptarangydi Ghanavati has moderate hypoglycemic and antihyperglycemic effect. |
