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ORIGINAL ARTICLE
Year : 2020  |  Volume : 41  |  Issue : 2  |  Page : 87-97

Effect of Opuntia elatior Mill. (Nagaphani) in the management of Pandu Roga w. s. r to iron deficiency anemia; an open labeled randomized standard controlled clinical trial


1 Department of Dravyaguna, Akhandanand Ayurved College, Ahmedabad, Gujarat, India
2 Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
3 Department of Kayachikitsa, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
Rabinarayan Acharya
Department of Dravyaguna, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ayu.AYU_31_18

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Background: Pandu Roga described in Ayurveda bears resemblance to the clinical features of anemia. The fruits of Nagaphani (Opuntia elatior Mill.) of family cactaceae, are consumed by the inhabitants of Gujarat as a hematinic agent to treat general debility and anemia. Aim and objective: To evaluate the efficacy of the O. elatior fruit juice in Pandu Roga with special reference to iron deficiency anemia. Materials and method: Present clinical study was an open labeled, randomized trial, in which 105 patients of Pandu Roga (iron deficiency anemia), were divided into two groups using the coin method of randomization. Group A received Opuntia elatior fruit juice, 20 ml twice a day with lukewarm water before meal. Group B received Punarnava Mandura (standard control), well accepted after this a herbo-mineral fromulation, two tablets of 500 mg each, twice a day with Takra (butter milk) before meal. Duration of intervention was 2 months in both groups and a follow-up of 1 month. The assessment was done based on the clinical signs and symptoms and hematological parameters such as Hb% (hemoglobin %), total red blood cell (TRBC), serum iron, serum ferritin and total iron-binding capacity (TIBC), before and after completion of the treatment. The data were subjected to statistical tests (Wilcoxon signed-rank test and paired t-tests, co-efficient of variance (CV)), and analyzed. Results: Both trial drug and the standard drug produced a statistically significant increase in Hb%, TRBC and serum Iron. The standard drug provided statistically significant increase (P < 0.05) in TIBC, whereas a statistically insignificant (P > 0.05) effect was observed in the trial group. Both trial and standard drug provided statistically significant (P < 0.001) relief in Panduta (pallor), Daurbalya (general weakness), Akshikutashotha (periorbital edema) and Pindikodveshthana (calf muscle cramps). When compared between the groups, the standard drug was found to be more effective than the trial drug. Conclusion: Fruit juice of Opuntia elatior is effective in iron deficiency anemia as it increases the hemoglobin, TRBC levels in blood along with providing relief in Panduta (pallor), Daurbalya (general weakness) Akshikutashotha (periorbital edema).


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