|Year : 2020 | Volume
| Issue : 4 | Page : 211-217
Efficacy of Guggulu and Shallaki based Ksharasutra with Triphala Guggulu orally in the management of Bhagandara w.s.r. to fistula-in-ano: A open labelled randomized comparative clinical study
Aditya Nema1, Sanjay Kumar Gupta2, Tukaram Dudhamal3, Vyasdeva Mahanta2
1 Department of Shalya Tantra, Pt. Khushilal Sharma Government (Autonomous) Ayurveda College and Institute, Bhopal, Madhya Pradesh, India
2 Department of Shalya Tantra, All India Institute of Ayurveda, Delhi, India
3 Department of Shalya Tantra, I.T.R.A., Jamnagar, Gujarat, India
|Date of Submission||30-Jun-2016|
|Date of Decision||21-Jun-2018|
|Date of Acceptance||17-Nov-2021|
|Date of Web Publication||03-Jun-2022|
Assistant Professor, Department of Shalya Tantra, Pt. Khushilal Sharma Govt, Auto Ayurveda College and Institute, Bhopal - 462 007, Madhya Pradesh
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Background: Bhagandara is a disease of ano-rectal region and can be correlated with fistula-in-ano. Ksharasutra (application of medicated thread) is being practiced for ano-rectal disorders, particularly in Bhagandara. Guggulu-based Ksharasutra has shown good results in previous studies. Literatures and experiments of Shallaki showed anti-inflammatory, antifungal, analgesic, wound healing properties and Shallaki Niryasa (resin of Boswellia serrate Roxb.) is also having binding effect. Here, Shallaki-based Ksharasutra is used in comparison of Guggulu-based Ksharasutra with Triphala Guggulu orally for better outcome in the management of Bhagandara. Aim: The aim of this study was to evaluate and compare the efficacy of Guggulu and Shallaki based Ksharasutra with Triphala Guggulu orally in the management of Bhagandara. Materials and methods: Total 46 patients were registered and randomly allocated by computer generated chart by into three groups. In group A (n = 15), Guggulu-based Ksharasutra was applied in fistula-in-ano without any oral medication; in group B (n = 16), Guggulu-based Ksharasutra was applied with Triphala Guggulu orally; and in group C (n = 15), Shallaki-based Ksharasutra was applied with Triphala Guggulu orally. Patients were assessed for pain, discharge, itching and swelling in the affected region and unit cutting time (UCT) of fistulous tract. Ksharasutra was changed by railroad technique on weekly based follow-up till complete healing of the tract occurred. Results: In group A, relief in pain, discharge, and swelling was found and was statistically highly significant while insignificant result was found in itching after cut through of the fistulous tract and the same results were found in group B (n = 14) and group C (n = 15). The mean UCT was higher in group A (8.94 days/cm) than in group C (8.43 days/cm) and in group B (8.59 days/cm). Conclusion: Shallaki based Ksharasutra is more effective in cutting of fistula track while Guggulu based Ksharasutra is more effective in pain relief in the treatment of Bhagandara, along with oral Triphala Guggulu as compared to Guggulu based Ksharasutra with and without Triphala Guggulu orally.
Keywords: Bhagandara, fistula-in-ano, Guggulu-based Ksharasutra, Shallaki-based Ksharasutra, unit cutting time
|How to cite this article:|
Nema A, Gupta SK, Dudhamal T, Mahanta V. Efficacy of Guggulu and Shallaki based Ksharasutra with Triphala Guggulu orally in the management of Bhagandara w.s.r. to fistula-in-ano: A open labelled randomized comparative clinical study. AYU 2020;41:211-7
|How to cite this URL:|
Nema A, Gupta SK, Dudhamal T, Mahanta V. Efficacy of Guggulu and Shallaki based Ksharasutra with Triphala Guggulu orally in the management of Bhagandara w.s.r. to fistula-in-ano: A open labelled randomized comparative clinical study. AYU [serial online] 2020 [cited 2022 Aug 19];41:211-7. Available from: https://www.ayujournal.org/text.asp?2020/41/4/211/346553
| Introduction|| |
In Ayurveda, Bhagandara (fistula-in-ano) is mentioned as one among eight major diseases (Ashto-Mahagada). In spite of many available surgical and para-surgical modalities, the recurrence rate of fistula is 20%–30%. On the other hand, Ksharasutra (medicated thread) therapy is practiced for fistula-in-ano with least recurrence rate (3.33%). The globally famous text book, “Bailey and Love's Short Practice of Surgery” included Ksharasutra as a treatment modality for fistula-in-ano. Sushruta had described the use of Kshara (alkaline ash) in Bhagandara. Later on Chakrapani and Bhavamishra had given detailed description of preparation and application of Ksharasutra in Bhagandara (fistula-in-ano).,
Ksharasutra is generally prepared with Snuhi Ksheera (latex of Euphorbia neriifolia Linn.), Apamarga Kshara (alkaline ash of Achyranthes aspera Linn.), and Haridra powder (Curcuma longa Linn.) which is called conventional Snuhi-based Ksharasutra but Guggulu-based Ksharasutra is found more beneficial than conventional Ksharasutra in previous studies. Moreover, Snuhi Ksheera is difficult to procure and preserve for long time. Hence, Niryasa (exudates) of Guggulu (Commiphora mukul Hook.) and Shallaki (Boswellia serrata Roxb.) were selected as alternative of Snuhi for preparing Ksharasutra in this study, as both are easily available and it is easy to prepare Ksharasutra. These are less irritant and have similar binding property as Snuhi Ksheera. In addition, Guggulu is used to treat Vrana (wound), Apachi (lymphadenitis), Pidika (boils), Granthi (cyst), Shopha (edema), etc., which shows that Guggulu is having antiseptic, anti-inflammatory, and wound healing properties and all these properties may increase the therapeutic effect of Guggulu-based Ksharasutra. Hence, this study was conducted with the aim to evaluate and compare the efficacy of Guggulu-based Ksharasutra and Shallaki-based Ksharasutra with Triphala Guggulu in the management of Bhagandara (fistula-in-ano).
| Materials and methods|| |
Approval from Institutional Ethics Committee was taken before starting study vide letter no. PGT/7/-A/Ethics/2014-15/1538 dated September 2, 2014. The trial had been registered in the Clinical Trials Registry of India (CTRI) prospectively with registration no. CTRI/2016/04/006825 [Chart 1].
Total 46 cases of Bhagandara (fistula-in-ano) were registered from outpatient department and inpatient department of the Shalya Tantra Department, IPGT&RA, Jamnagar. They were randomly allocated into three groups adopting computerize randomization as follows:
- Group A (n = 15): Local application of Guggulu-based Ksharasutra alone was done
- Group B (n = 16): Local application of Guggulu-based Ksharasutra was done with Triphala Guggulu orally
- Group C (n = 15): Local application of Shallaki-based Ksharasutra was done with Triphala Guggulu orally.
Guggulu and Shallaki based Ksharasutra were prepared at the Department of Shalya Tantra by adopting standard API methods of Ksharasutra preparation.
Initial weight of 30-cm long Barbour surgical linen thread no. 20 was 0.2 gm. After preparation of Guggulu and Shallaki based Ksharasutra, it was 1.2 g and 0.9 g, respectively.
Common materials for preparation of Ksharasutra are as follows:
- Barbour surgical linen thread number 20
- Apamarga Kshara (solidified water soluble of A. aspera Linn.)
- Haridra (C. longa Linn.) powder
- Ashodhita Guggulu (C. mukul Hook.) exudate
- Ashodhita Shallaki (B. serrata Roxb.) exudate.
Guggulu based Ksharasutra was prepared with Guggulu exudate and Shallaki based Ksharasutra was prepared with Shallaki exudate by replacing Snuhi Ksheera.
Triphala Guggulu was prepared at pharmacy of study center by adopting classical method.
Diagnosis was made on the basis of clinical complaints, per anal inspection, palpation, digital examination, proctoscopy, and required investigations as per specially designed research proforma.
Patients of age between 20 and 60 years were included in this study.
The patients with associated diseases like osteomyelitis of pelvic bone, chronic or acute ulcerative colitis, Crohn's disease, anorectal or any other malignancy, human immunodeficiency virus (HIV) and hepatitis B surface antigen (HbSAg)-positive cases, pregnant ladies and fistula other than ano-rectal and uncontrolled cases of diabetes mellitus, hypertension and tuberculosis were excluded from this study.
Total leukocyte count, differential leukocyte count, hemoglobin, erythrocyte sedimentation rate, bleeding time, clotting time, fasting blood sugar, blood urea, serum creatinine, serum bilirubin, HIV, HbSAg and routine urine examinations were done in all patients before Ksharasutra application. Biopsy of the tissue of the tract was done in suspected cases of malignancy.
- Written informed consent of every patient was taken before surgery
- Patients were kept nil by mouth 6 h prior to procedure
- Lignocaine sensitivity test was done (0.1 ml intradermal)
- Injection tetanus toxoid 0.5 ml intramuscular was given
- Part was prepared (local shaving) before operation
- Proctoclysis enema was given in the morning on the day of surgery.
Painting and draping of perianal area was done after giving low spinal anesthesia. In lithotomy position, first methylene blue dye was passed in the tract to locate the direction and course of fistula. Then, probing was done to confirm the communication for two openings, a malleable probe was inserted into the tract that reached to internal opening by applying least resistant area. After piercing the internal opening, the tip of the probe came out through the anal canal. In patients of group A and group B, Guggulu based Ksharasutra was applied, while in patients of group C, Shallaki based Ksharasutra was applied. The two free ends of Ksharasutra were tied over keeping it loose. In multi-branching or high anal fistula-in-ano, tract was partially excised for proper drainage. “T” bandage was applied after sterile dressing.
- Patients were kept nil by mouth and head low position was maintained for initial 6 h after surgery
- Injection cefotaxime 1000 mg + sulbactam 500 mg intravenous two times a day in postoperative period and tablet aceclofenac 100 mg + paracetamol 325 mg + serratiopeptidase 15 mg were also given after meal two times a day for 3 consecutive postoperative days.
- Patients were advised to start warm water sitz bath with Panchavalkala Kwatha (Nyagrodha – Ficus benghalensis Linn., Udumbara – Ficus glomerata Roxb., Ashwattha – Ficus religiosa Linn., Parisha – Thespesia populnea Soland ex Correa, and Plaksha – Ficus lacor Buch.-Ham.) from the next day of operation
- 10 ml of Jatyadi Taila was administered per rectal two times a day, morning and evening after sitz bath
- Erandabhrishta Haritaki powder, 5 g with lukewarm water at bedtime, was prescribed
- In patients of group B and group C, Triphala Guggulu 2 tabs of 500 mg, twice a day after meal with lukewarm water, were given
- Ksharasutra was changed by railroad technique at every 7th day till cut through of tract.
Guggulu and Shallaki based Ksharasutra were prepared in the Department of Shalya Tantra, IPGT and RA, Jamnagar, and Panchavalkal Kwatha, Jatyadi Taila, Erandbhrishta Haritaki, and Triphala Guggulu were prepared in Gujarat Ayurved University Pharmacy, Jamnagar, adopting standard API method of preparation. After healing of fistulous tract, all patients were followed till 1 month at weekly interval.
Criteria for assessment
The assessment was done on the basis of objective parameter, i.e., unit cutting time (UCT) [Table 1],[Table 2],[Table 3],[Table 4] and subjective parameters such as relief in symptoms of pain, discharge, itching, and swelling [Table 5],[Table 6],[Table 7],[Table 8].
The data obtained in clinical study were subjected to statistical tests such as Wilcoxon signed-rank test, Kruskal–Wallis Test, and ANOVA test with the help of Sigma State. After obtaining P value, it was observed as insignificant P > 0.05, significant P < 0.05, highly significant was P < 0.01.
In the enrolled cases of Bhagandara, no patient had a history of diabetes mellitus, hypertension, and tuberculosis. All the patients were observed for type of Bhagandara according to classification given by Ayurvedic classics, and it was observed that maximum (41.03%) patients were having Riju type of Bhagandara.[Table 4] As per contemporary medicine, among the case of Bhagandara, maximum cases were of low anal type fistula. All patients were examined for type of fistulous tract and number of external opening, and it was seen that maximum (52.17%) patients had complete type of fistulous tract and maximum (80.43%) patients had single external opening. [Table 2] Maximum (59.28%) patients had external openings at posterior side of anus. [Table 3].
| Results|| |
In this study out of 46 patients, total 44 patients completed the treatment, i.e., 15 patients in group A, 14 patients in group B, and 15 patients in group C. Two patients of group B were dropped out due to long distance of hospital from their home but continued treatment at their respective places. In group A (n = 15), the results on the symptoms of pain, discharge and swelling were found statistically highly significant while insignificant result was found in itching after cut through of the entire fistulous tract [Table 9]. The same statistical results were found in group B (n = 14) and group C (n = 15) [Table 10] and [Table 11]. On comparison between groups, no significant difference was found statistically [Table 12]. Moreover, all 44 registered patients completed the course of treatment and got relief.
|Table 12: Comparative effect of therapy in between of three-group Kruskal-Wallis test (h) test and ANOVA (f) test used for comparison of all groups|
Click here to view
After every change of Ksharasutra, the length of the thread was measured and recorded in research proforma. The individual patient's UCT was calculated and the comparison was made with the mean UCT of all three groups. In group A, the mean UCT was 8.94 days/cm. In group B, the mean UCT was 8.59 days/cm, whereas in group C, the mean UCT was 8.43 days/cm. No adverse drug reaction was reported during the course of study and follow up period. No recurrence was observed in any patient during follow up [Table 14].
|Table 13: Mean unit cutting time: Table made by applying ANOVA test on unit cutting time of all groups|
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| Discussion|| |
Total 52.17% of patients were diagnosed as complete type of fistula due to recurrent infection and discharge present from fistulous tract. 43.47% of patients were diagnosed with blind external due to closing of the internal opening by fibrotic changes. The fistula-in-ano usually originates from a perianal abscess in the inter-sphincteric space and infection of anal gland (cryptoglandular infection). Due to the tone of internal sphincter, the duct cannot appropriately discharge so the abscess usually tracks down and opens through a fistulous tract at the perianal skin externally and some time it can get closed for time being. The position of external opening at posterior half was maximum i.e. 59.28% as anal glands are 4–8 in number and most of them are situated at posterior aspect of anal canal. The curved fistulous tracts were noted in 54.34% of patients as external openings are present at posterior part of anus which opens internally on midline at 6 O'clock (Goodsall's rule). Previous research work of Cirocco and Reilly also reported a similar finding. In all three groups, significant improvement was found on symptoms of pain, discharge and swelling and insignificant result found in itching. Insignificant result in itching might be due to continuous discharge from fistulous tract. Triphala Guggulu orally given in group B and group C did not showed any additional effect as compared to group A. Clinically, results of all three groups were almost similar and statistically insignificant difference was noted [Table 12].
The lowest UCT was found in group B which was 4 days/cm, where the length of the tract was 3 cm. The highest UCT was also found in group B which was 14 days/cm where the length of the tract was 10 cm. Although the length of the tract was small, even then it took more time to heal which shows the callous nature of healing of the fistulous tract. The mean difference between UCT was minor in between groups, but on looking the group statistics, it was found that in group A, 7 patients and, in group B, 6 patients have UCT of 10 days/cm or more than 10 days/cm, while in group C, only in 2 patients, UCT was more than 10 days/cm that shows the effect of Shallaki based Ksharasutra in group C. UTC was least in group C as compare to other groups but Shallaki based Ksharasutra showed more pain as compare to other group. Guggulu-based Ksharasutra was comparatively smoother, because after preparation, Guggulu Niryasa consistency was soft and more uniform on thread that's why less irritant and less painful. In the comparison of UCT of Fistulous tract of all three groups, group C showed good cutting power but the healing of fistulous tract required its own time.
Overall, all three groups were effective in Bhagandara with complete cure. However, on the prospects ground of less UCT, group C was found better than group A and group B [Table 13].
Apamarga Kshara has properties of Kshara, i.e., Chedana (excision), Bhedana (incision), Lekhana (scrapping), and Tridoshaghna (alleviating all Dosha). Haridra powder has the properties such as Rakta Shodhaka (blood purifying), Shothahara (anti-inflammatory), Vatahara (alleviate Vata) and Vishaghna (antimicrobial), and it is useful in Vrana-Ropana (wound healing). Guggulu has properties of Laghu (lightness), Ruksha (dryness), Ushna-Veerya (hot potency) and Sara (the quality of a substance which is responsible for flow), etc. It is Kapha-Vatahara (relives Kapha and Vata), Kledahara (remove moistness/soddening), and Jantughna (antimicrobial) and is useful in Vrana (wound), Apachi (lymphadenitis), Pidika (boils), Granthi (cyst), Shopha (edema), Arsha (piles), Arbuda (tumor) etc. Shallaki Niryasa has Kashaya (astringent taste), Tikta Rasa (bitter taste), Ruksha (dryness), Laghu Guna (lightness property), Katu Vipaka, Ushna Veerya (hot potency) and Kapha-Pitta Shamaka (relives Kapha and Pitta) properties. It is Vrana-Shodhaka (wound cleanser), Vrana-Ropaka (wound healer), and Puyahara and indicated in Vrana (wound), Atisara (diarrhea), Timira (errors of refraction/partial blindness), Rakta-Pitta (hemorrhagic disorder), Kushtha (various skin diseases), etc. Boswellic acid helps in getting rid of foul odor and eliminating any pest in the surroundings and makes wound healing faster. Guggulu helped in Shodhana and Ropana of path of fistulous tract. Due to Jantughna properties of Guggulu (C. mukul), it is also used for treatment of infection. Therefore, Triphala Guggulu act as anti-inflammatory, analgesic and antibiotic drug. Panchavalkala Kwatha sitz bath helped to reduce local congestion and inflammation and thus relieved pain by improving local circulation and promoting healing., Jatyadi Taila has Shodhana (wound cleaning) and wound healing properties and helped for wound healing in Bhagandara (fistula-in-ano)., Haritaki (Terminalia chebula Retz.) has properties that is Dipana (metabolism enhancing effect), Pachana (digestive), and Anulomana (regularizing physiological movement) and helped to regulate bowel habits in all patients postoperatively.
The Ksharasutra has a combined effect of all ingredients by which it renders in cutting and healing of the fistulous tract. Ksharasutra cuts unhealthy portion of the tract and provides simultaneous healing. Hence, it UTS the track by weekly after changing Ksharasutra which is UCT. The Ksharasutra also helped to cut the fistulous tract by exerting mechanical pressure over the enclosed tissue. Healing from the base of the fistulous tract runs parallel to the cutting of tract. Ultimately, Ksharasutra comes out by cutting through the entire fistulous tract with simultaneous healing from its base. At last, a small linear scar remains at the site of fistula.
| Conclusion|| |
Guggulu based Ksharasutra and Shallaki (B. serrata Triana and Planch.)-based Ksharasutra both are found equally effective in the management of fistula-in-ano. Shallaki based Ksharasutra is more effective in cutting of fistula track while Guggulu based Ksharasutra is more effective in pain relief in the treatment on Bhagandara. Hence, it can be concluded that Guggulu based Ksharasutra can be used in cases of Pitta predominant (Ushtragreeva Bhagandara) cases and Shallaki-based Ksharasutra can be used in recurrent and fibrosis cases of fistula more effectively.
We would like to thank Prof. M.S. Baghel, Ex-Director, IPGT and RA, Gujarat Ayurved University, Jamnagar.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7], [Table 8], [Table 9], [Table 10], [Table 11], [Table 12], [Table 13], [Table 14]