Makaradhwaja is a well known Ayurvedic medicine prepared by Kupipakwa method. It is prepared by using shuddha Swarna (Gold), Astasamskarita Parada (Mercury) and shuddha Gandhaka (Sulphur) in the ratio of 1:8:16 as ingredients. The present study was under taken to ascertain the safety aspect of the drug through acute and chronic toxicity studies. Acute toxicity study was carried out in Swiss albino mice and chronic toxicity study was carried out in Charles Foster albino rats at different dose levels. The parameters studied were ponderal, haematological, biochemical and histopathological. in case of chronic toxicity study, mortality and behaviour change in acute toxicity. In acute toxicity study the test drug did not produce mortality up to the dose of 480 mg kg-1 (orally) in mice. The result or data obtained during the study indicate no significant changes observed in hematological, biochemical and histopathological parameters except of mild increase in blood sugar level and mild fatty changes in liver.

Ayurveda has taken the foremost place in the management of crippling discase. Amavata is one of them. From the modern point of view, this disease looks similar to Rheumatoid arthritis in its clinical appearance. In the whole world rheumatic disease are commonest cause of physical impairment in society. The lives of more than one million people are physically impaired by rheumatic disorders and fifth of these are severely disabled. Due to its wide prevalence chronicity, morbidity, crippling nature and lack of effective drugs attract to look for suitable remedy of the disease Amavata. Bhallataka and Guduchi are the Rasayana drugs, so in general they improve the qualities of body element thereby curing the disease as well as maintaining the healthy state of the body. But, there were many side effects noted in previous research works on Bhallataka. So to search for better form or acceptable form of Bhallataka as well as to use combination of two Rasayana drugs, for the present study as Shamana therapy Amritabhallataka has been chosen. Which is mentioned in Bhavaprakash Madhyama Khanda 54/75-82. Virechana is mentioned in Chakradutta Chikitsa Sutra and many work with Virechana Karma on Amavata have been successfully carried out. So in this study Virechana has been conducted. Total 35 patients of Amavata were treated. These patients were randomly distributed into two treatment groups. Amritabhallataka without Virechana (14 patients) and Amrita Bhallataka with Virechana (11 patients) were taken. Out of above said group. The improvement was statistically highly significant in both the groups, but comparatively Shodhana group (group B) had better relief than Shamana group (group A) Amrita Bhallataka Avaleha was well tolerated by most of the patients (31), very minor side effects observed in few (4) patients.

Shirisharishta is a compound formulation having main content as Shirisha. Shirisha (Albizia lebbeck Benth.) is a well known classical drug for the treatment of various types of diseases such as Shwasa, Kasa etc. The plant is reported to have various pharmacological properties like anti-asthmatic, antihistaminic, anti-protozoal etc. Most of the recent studies are reported about the pharmacological actions of it's bark, leaves, pods and fruits, but almost negligible references about the pharmacological action of it' heartwood are available. Nowadays Twak (bark) is commonly used for the preparation of Shirisharishta, but Sara (heartwood) is the part which is indicated in Asava Yoni. Shwasa Roga (Asthma) is one of the most common chronic diseases in the world. It may be defined as a disease in which the respiration is disturbed due to narrowing or obstruction in the channels. Bronchial asthma is a common disease affecting 10% to 20% of population. Considering the above facts in the present study Shirisharishta was prepared by Twaka (bark), Kastha (sapwood) and Sara (heartwood) of Shirisha. Pharmacologically Shirisharishta prepared by Sara shows significant result in anti-inflammatory and anti-tussive actions and significant increase in anti-histaminic activity while better activity profile in CMI suppression activity than the other two groups of Arishta. Clinical study on 41 patients also supports the experimental data in which Shirisharishta prepared by Sara shows better result in curing the disease Shwasa (Asthma).

Cancer is one of the most dreaded disease of 20th century and spreading further with continuance and increasing incidence in 21st century. Any practical solution in combating this dreadful disease is of paramount importance. No cure should be hazardous than the disease, however chemotherapy opposes this principle and it further worsens the crippled cancer patients with its side effects. Therefore an integrated approach is needed to manage cancer and the chemotherapy induced side effects. At this stage Ayurveda offers Rasayana as the best tool to manage the chemotherapy induced toxicities like nausea, vomiting, alopecia and myelosuppression.