Ayurveda have veritable abundance of number useful drugs, belonging to herbal, animal, mineral origin used as a single drug or in compound formulations. Asava -Arishta having palatable taste, quick action longer shelf life and can be easily administered to the patients. In the present study Lohasava and its effect in the management of Pandu Roga is studied. Four different samples (I-IV) of Lohasava are prepared out of these four samples, three samples (I-III) contains Lauh Bhasma, while sample IV incorporated with Lauh Churna as per the original reference and all the different samples administered to the four different groups of anaemic patients, each group having 10 patients. Symptomatic relieve observed, in all the groups of patients, but it was also observed that patients of group III, having maximum symptomatic relief, than other groups. The various haematological parameters, are also improved in all groups, it is also noticed that sample I, II is found to be more effective, than sample IV in improving Hb level (p<0.05), while sample III, is better (p<0.01) than sample IV in increasing Hb level and total RBC count. Therapeutic efficacy of all the four samples has been found to be effective, in the management of Pandu Roga. Among them the sample III showing better efficacy, compared to all samples. Sample III has been prepared by fermenting in the china clay container.

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This study has been carried out to compare the Psycho-neuro-pharmacological basis for the use of Guduchyadi Ghrita and Bhringarajadi Ghrita. Guduchyadi Ghrita Rasayana consisting of Guduchi (Tinospora cordifolia Linn), Apamarga (Achyrenthus aspera Linn), Vidanga (Embelia ribes Burm. F.), Shankhapushpi (Convolvulus pluricaulis Chois), Vacha (Acorus calamus Linn), Haritaki (Terminalia chebula Retz), Kushtha (Saussurea lappa C.B.Clarke ) and Shatavari (Asparagus racemosus Willd), has proven mental health promoting, memory enhancing, anti-stress, anti- depressant properties that may slow down the Aging process by counteracting stress. Bhringarajadi Rasayana consisting of Bhringaraja (Eclipta alba Hassk.), Krishna Tila (Sesamum orientale Linn.), Amalaki (Embelica officinalis Gaertn.), Mishri (Sugar) with proven adaptogenic, antioxidant, free radicals scavenger, immuno-modulator properties play a major role in the management of Aging process. Both the formulations are supposed to possess CNS activity, Anti-stress, adaptogenic and other pharmacological activities. Based on this promise the test Ghrita had been studied on various experimental models such as Gross behaviour test, Anti depressant test, Anti-anxiety test and Antistress adaptogenic test on Swiss Albino Mice and Charles Foster strain albino rats of either sex. On Gross behaviour study, both the test drugs showed hypoactivity. In the Anti depressant activity, Guduchyadi Ghrita showed significant decrease in the Mice Behavioral "despair" test, moderate decrease in Mice immobility in Chronic fatigue syndrome test and produced potentiation of L dopa effects. Bhringarajadi Ghrita showed no discernible Anti depressant and Chronic fatigue syndrome test though moderate potentiation of L dopa effect was observed. Guduchyadi Ghrita also produces antianxiety activity and Adaptogenic activity. None of the formulation was able to reverse stress induced Hypothermia. Slightly higher decrease in stress induced ulceration was observed with Guduchyadi Ghrita, however Bhringarajadi Ghrita had no effect. No statistically significant effect observed on Haematological, Biochemical parameter and DHEA-S (Dehydroepiandrosterone Sulfate). Guduchayadi Ghrita showed marginal elevation of DHEA-S level.

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Rasakarpura, a Nirgandha type of Kupipakva Rasayana, used to cure skin disease. Although various references of Rasakarpura preparation are described in different Rasa Shastra classics but for the present study the reference of Rasatarangini (6/65-71) was selected. Rasakarpura is prepared with Parada, concentrated sulphuric acid and Saindhava Lavana in the ratio of 1: 1΍ and approx 1΍ respectively by using Valuka Yantra in Classical method within 9 hours of heat treatment and in Mechanized method by using electric muffle furnace (EMF) within 12 hours of heat treatment. Analytical study was done to find out its major chemical constitutes i.e. mercuric chloride along with sodium, magnesium and calcium as trace elements for product standardization.

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Acaryas lay emphasis on the significance of the Pancamahabhutas in understanding Shareera when they state their involvement from conception to death i.e. from the four Bhutas which enter Garbha1, the Pancabhautika Prakriti2, the Saddhatvatmaka Purusha3 termed as Cikitsadhikrita Purusha to the Pancabhautikatva of indriyas4, till death quoted as Pancatvagatam5, each of the above references show a special relevance to Mahabhutas. An attempt is made in this study to evaluate the utility and applicability of this principle of Pancamahabhutas in day to day practice. There are enough evidences in the treatises to prove that these Pancamahabhutas and the phenomenon of Panceekarana6 mentioned in terms of Samyoga dharmas7 was used to understand and treat diseases. In support of the above concept a study on the patients of Santarpanottha Prameha has been carried out by dividing them in two groups, Group A & Group B. Here the drugs were selected on the basis of the hypothesis that the vitiated gunas of one particular group of Mahabhutas can be countered with the administration of dravyas having opposite Mahabhautika guna dominancy8, i.e. Akasha, Vayu, Prithvi, or Agni. In Group A - Triphaladi Yoga was administered. In Group B - Citraka Curna was given9. The result was assessed after six weeks with the help of a specially prepared Proforma. All the important haematological, Biochemical & Urine investigations were done. Symptomatically significant results were found in Group A as compared to Group B.

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