Allergic rhinitis is an atopic disease. Atopic allergy is a type-1 hypersensitivity reaction which produces IgE antibodies to allergens viz. pollen, dust, etc. In Ayurveda direct reference of allergic rhinitis is not available, but concept of allergy is scientifically explained under 'Asatmyaja Vyadhi' while its effects are explained in context of hereditary, Viruddhahara, Dushivisha and Ritu Sandhi. Various types of Pratishyaya are explained clearly in all samhitas. However, symptoms of Vataja pratishyaya like Tanu Nasa Srava, Shirashoola, Kshavathu etc. more related with symptoms of allergic rhinitis. In the present study, patients of allergic rhinitis are evaluated on the basis of general evaluaton scale consisting parameters like nasal obstruction, sneezing, itching etc. Total 69 patients were selected and randomly divided into 3 groups viz : 1) Shunthi tail Nasya for 14 days, followed by internal drug Sudha Haridra 2 gms TDS. for 21days; 2) Pradhamana Nasya with Katphal churna till samayaka shuddhi lakshana obtained ,followed by internal drug Shuddha Haridra 2 gms TDS for 21days; 3) Only oral drug Sudha Haridra 2 gms TDS for 21 days. It was observed that symptoms like sneezing, rhinohorrea, headache, itching were almost completely relieved in all groups.

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Kidneys are among the highly vascularised organs receiving around 20-25% of the cardiac output. Because of this reason they are constantly exposed to xenobiotics including environmental pollutants, many a times leading to impairment and damage to the kidney. In such a situation, availability of nephroprotective drugs would serve very important therapeutic purpose. In Ayurveda several drugs are used as nephroprotectives and this group of drugs acts as good non-specific cytoprotectives. In this context ayurvedic classical formulations, Ashmarihar kashaya (Siddha yoga samgraha chap. 18) and Nagaradi kashaya (Chakradatta chap. 28) were studied as nephroprotective agents in the present experimental study on Albino rats. The results were assessed by using a battery of parameters i.e. serum biochemical parameters, biochemical parameters in kidney homogenate and histopathological study of the kidney and heart. It was observed that the gentamicin and cisplatin induced nephropathy was mild to moderately antagonized by using Ashmarihara kashaya; while, no antagonism of nephropathy was noticed in Nagaradi kashaya as nephroprotective agents. Surprisingly, it was seen that, both drugs produce mild to moderate cardioprotective effect against gentamicin and cisplatin induced cardio-toxicity.

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Migraine is one of the common causes of recurrent headache. According to IHS, Migraine constitutes 16% of the primary headache and affects 10-20% of the general population. The diagnosis is mainly based on clinical history. Moreover, unilateral headache with paroxysmal nature is the only symptom mentioned for the disease Ardhavabhedaka by ancient scientists. Ardhavabhedaka has been explained as Tridoshaja by Acharya Sushruta, Vata-Kaphaja by Charaka and Vataja by Vagbhatta. But the different quality of pain such as Toda, Bheda, etc. describes the Vishama nature of Vata dosha. A study in 2002 that analyzed over 800,000 cases of migraine reported that most migraines are not treated according to any expert recommendations or accepted evidence. Our Acharyas have mentioned Nasya Therapy as the master key for all urdhavajatrugata vikaras. Considering all such things the present study was selected, in which total 44 patients were registered and were randomly divided into two groups. In group A, Laghu Sutashekhara Rasa & group B, Brihat Dashamoola Taila Nasya along with Laghu Sutashekhara Rasa was given for 6 weeks. In group A & in group B, maximum number of patients i.e., 35% & 52.94% respectively showed marked improvement.

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Guduchi (Tinospora cordifolia (willd) Miers.), is a well-known herbal drug used as a potent Rasayana (rejuvenating), Raktashodhaka (blood purifier), Kushthaghna (drug for skin diseases), Medhya (brain tonic) and Tridoshahara (pacify the three aggravated Doshas) drug in different dosage forms. Guduchi taila and Guduchi ghrita are examples of Sneha kalpana (Oleagenous formulations) described for the treatment of Kushtha roga (skin diseases) by Acharya Chakradatta. Thus in this study both Guduchi taila and Guduchi ghrita were prepared by utilizing Guduchi kalka, Guduchi kwatha and Go-dugdha along with Murchhita tila taila and Murchhita go-ghrita. All the samples were analyzed on various organoleptic, physicochemical and phytochemical parameters for developing the standards for the formulations. Total eight samples of Guduchi taila and five samples of Guduchi ghrita were prepared by following classical method to maintain process uniformity and to validate the standard procedure. Thin Layer Chromatography profile of the test formulations were also carried out to establish the chromatographic profile for the same. Thin Layer Chromatography study shows more number of spots in Guduchi taila in comparison to Ghrita preparation.

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Vicharchika, a Kshudra Kushtha though involves only epidermis, its tendency of recurrences continues to pose problems to the physician. In allopathic medicine, it can be co-related to Eczema, a disease which is resultant of delayed type hypersensitivity mediated by memory T lymphocytes in the skin and the clinical lesions may be acute (wet and edematous) or chronic (dry, thickened, and scaly), depending on the persistence of the insult . In this study, out of 46 patients registered, 33 completed the treatment. These patients were treated with : Shirishadi Decoction (30 ml) twice daily along with the local application of Snuhyadi Lepa for the duration of 60 days. Results of the study revealed that Shirishadi Decoction and Snuhyadi Lepa provides significant relief in the signs and symptoms as well as eosinophil count of the patients of eczema.

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Karshya is the most wide spreading health and nutritional problem in developing countries. Protein energy malnutrition is a possible condition which may be correlated with Karshya. The present study was undertaken to find out the effect of Vidarikandadi Vati and Kshirabala Taila Basti in the management of Karshya in children. Thirty patients were studied and randomly divided into two groups namely Group-A and Group-B. Group-A received Vidarikandadi Vati and Group-B received Kshirabala Taila Basti. Effect of drugs was observed at the end of thirty days. In group-A, 13.33% patients showed moderate improvement and 86.67% patients showed mild improvement, marked improvement was not found in this group. In group-B marked, moderate and mild improvement was observed in 13.33%, 73.33% and 13.33% respectively. It was concluded that Kshirabala Taila Basti is useful for the management of Karshya in children when compared to Vidarikandadi Vati.

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A randomized Survey study was done on healthy volunteers to evaluate effect of Ritu on Bala, as mentioned in Charaka-Sutrasthana-6/8. According to which, the beginning of the Visarga kala i.e Varsha and the end of the Adana Kala i.e. Grishma Ritu mark the Daurbalya (Decreased Bala) of the Human being. While the end of Visarga Kala i.e. Hemanta and the beginning of Adana Kala i.e. Shishira Ritu signify maximum Bala and middle of the both Kalas i.e. Sharad & Vasanta Ritu respectively medium Bala is observed. To prove the validity of the principle Sutra, 95 healthy volunteers were registered, out of which 80 continued throughout the study period for the Bala assessment. The Bala assessment was performed with the help of a specific scoring pattern based upon 12 parameters (from Ayurveda as well as Modern science), in three different Ritus viz. - Hemanta, Vasanta and Varsha. The study illustrated significant to highly significant differences in the most of the parameters, which is supportive to the selected Sutra that the maximum Bala is found in Hemanta Ritu, medium Bala in Vasanta while minimum in Varsha Ritu.

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The formulation 'Guduchi Ghana' was selected for the comparative study considering the market demand. The concentrated extracts of single or compound drugs are nowadays very familiar to the pharmaceutical industry. The concentrated form of any drug achieves more active constitutes than that of the powder of the raw material, even the dose is also comparatively lesser than that of the powder form. In the present study, Guduchi Ghana was prepared by two methods i.e. from Kwatha as per the reference mentioned in Siddha Yoga Sangraha and aqueous extract prepared by Soxhlet extraction procedure. Both the test drugs were prepared in three batches to maintain the Standard Operating Procedure (SOPs). Percentage yield of Guduchi Ghana prepared by Kwatha was obtained more (2.56 %) in comparison to the Soxhlet extraction method.

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Ayurvedic drugs containing Guggulu are predominantly used in Vataja disorders, where pain is the foremost symptom. Hence it was thought that Guggulu might be having analgesic effect. This research paper deals with various experiments on 20 albino rats to ascertain analgesic effect of Guggulu.

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Tamakashvasa as described in Ayurveda is a disease of Pranavaha Srotas (Respiratory system) involving multiple etiopathogenesis. The clinical features are nearly similar to that of Bronchial asthma described in Modern medicine. This study was designed to explore the therapeutic effect and synergistic action (if any) of a plant Tamalaki (Phyllanthus fraternus Webster). Tsmalaki is included in Shvasahara and Kasahara groups, used in many formulations prescribed in Shvasaroga in Ayurveda. Research works suggest its antihistaminic property in experimental model and effective in non bacterial upper respiratory disorders. The present study comprises 3 groups (each 10 patients). Group A was treated with trial drug Ghanasattva of P. fraternus Webster, 500mg, thrice daily, orally; while Group B was treated with modern standard drugs (a) Tab. Theo-asthalin, thrice daily, orally and (b) Asthalin inhaler, SOS and Group C as combination of both therapies. Total duration of treatment was 45 days. The observations reveal that, Group A has much better improvement in increasing Jaranashakti (t=7.57; p<0.001) and Ruchi (t=9.86; p<0.001) in comparison to Group B and Group C. Moreover, Group C was found more effective in reducing majority of sign-symptoms as such Breathlessness (t=9.00; p<0.001), Cough (t=6.47; p<0.001), Expectoration (t=9.00; p<0.001) Wheezing (t=7.96; p<0.001), Rhonchi (t=7.96; p<0.001), Jaranashakti (t=4.71; p<0.01) and Ruchi (t=6.68; p<0.001).

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Delonix elata (L.) Gamble (Poinciana elata Linn) commonly known as ''Sandesaro" in Gujarati, is a reputed folklore remedy used for arthritic disorders in many parts of Gujarat. Efforts were made to establish identity and quality of the leaf. Diagnostic microscopic characters were found to be long, narrow palisade cells, multicellular headed sessile glandular trichomes, crystal fibres and simple unicellular short trichomes. Quality parameters such as total ash (2.48 %) , water soluble ash (2.06%), acid insoluble ash (0.4 %), methanol soluble extractive (25.72%) have been established as per pharmacopoeial requirements. Qualitative tests indicated the presence of phenolic compounds and Thin Layer Chromatographic studies confirmed the same. Dravyaguna studies revealed its pradhana rasa as Kashaya and anurasa as Madhura.

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The study was conducted in 64 clinically diagnosed cases of Amavata (Rheumatoid Arthritis) with objectives of clinical evaluation of Alambushadi compound combined with the Alambushadi Niruha Vasti in the management of Amavata on the basis of various scientific parameters. Statistically significant improvement was observed in clinical, functional and hematological parameters in patients of group A (Alambushadi Group) and no improvement was observed over these parameters in patients of group B (Placebo group) after the completion of the course of treatment. Alambushadi Compound has been found to be an effective therapeutic regimen in the management of uncomplicated cases of Amavata with duration of illness less than 5 years.

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Syndrome-X has emerged as an area of special interest to medical faculty as it houses worst lifestyle pathologies in one patient. There being unknown common ground to Diabetes Mellitus, Hypertension, Obesity & dyslipidemia, the nomenclature adopted is Syndrome-X. As these diseases are observed to be led by Diabetes Mellitus, the other names of the syndrome are Metabolic Syndrome & Insulin resistant syndrome. This is why the Ayurvedic name attributed is 'Santarpanottha Madhumeha Vishesha'. The present study was aimed at observing & evaluating the common Nidana along with a comparative clinical study of two herbo-mineral compounds. 100 diagnosed patients of Syndrome-X were selected and randomly divided in two groups of fifty patients each; Group-A receiving Compound - A, Whereas Group-B receiving Compound - A with Medohara (Navak) Guggulu respectively. The vehicle for both the groups was Dashamoola decoction in a dose of 40 ml twice a day for 45 days. It was observed that most patients in group -B had significant improvement in Shrama, Prabhoot mootrata, Daurbalya, Vibandha, Kanthatalu shosha, Pipasadhikya & Sada.

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The plants developed with the disease fighting inherited natural character on the basis of specific chemical condensations are called 'medicinal plants'. The drug potential of the medicinal plants however, is restricted with the limited concentrations of chemicals responsible for disease curing character. Making use of this criteria our experts in medical sciences developed the modern medicines as the dense concentrations of disease fighting chemical drugs either by chemical synthesis or extracting from the medicinal plants. Now, since such chemical condensations are not natural, hence they decay with time. In order to make the modern medicines sustainable, an extra combination of chemicals is artificially attached, hence their expiry date is elongated a bit. Since this extra attachment of chemicals is not natural, that is why the allopathic medicines become time barred and imposing side effects on the patients treated with these medicines. An attempt is being made to enrich the medicinal plants with the disease fighting chemicals having their grown up medicine-index (MI) under Radioactivity Magneto-Radio-Frequency (MRF) interactions activating nano-excitations in these species. The nano-structurings in medicinal plants had been experimentally confirmed by trans-conductance second derivative peak structures using their magneto-potential records under Radioactivity & MRF-perturbations. Radioactivity-MRF-Nano excitations on medicinal plants Aloe Vera, Catharanthus Roseus had grown up their medicinal index (MI), 11 & 8 times greater respectively.

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Library of Gujarat Ayurved University is rich in collections of manuscripts and many other valuable literatures. Total number of manuscripts in the library is 7350; it is preserved in university library as a property of Gulabkunverba Ayurvedic Society and Government of Gujarat. These manuscripts had been handed over to Government of Gujarat by the Ex. Princely State of Gondal Shri Bhagwat Sinhji. Efforts are being made by research scholars for their publication. One of such manuscript is 'Sarasangraha' written by Atreya and the Literary Research Unit has done the translation of the same in Hindi, along with comparative study, which is being published here. In this manuscript, the author has made every effort to make it as a book for common man so that he can utilize the knowledge for primary or initial/simple treatment. It is a compilation of different Samhita granthas and made a clinical book for public use. The author himself admits in the text that Anya granthat samasena likhitam sarasangrahah I Pathyatam tu visheshena yena vaidyabhidho bhavet II - means this book is a compilation of all the Ayurvedic literatures in concise manner so that the knowledge seeker can gain more clinical knowledge in one book. With regards to the time period of the manuscript, it is inscribed at the end of the manuscript 'Samvat 1920' and the transcripter was Shri Chaturbhuj Dave, a resident of Bhujnagar. He compiled this book by knowledge of Basic principle of Ayurveda and clinical subjects, after offering prayers to God Dhanvantari, he described the Nadi pariksha in the manuscript.

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